It can be eliminated predominantly by hepatic metabolism (mostly CYP3A4) and is transformed to an Lively metabolite with Homes similar to the mother or father, sildenafil. Both sildenafil and the metabolite have terminal 50 % life of about four several hours.
The information down below describes dosages that are generally utilised or proposed. But be sure to take the dosage your physician prescribes for yourself. They’ll decide the best dosage to suit your requires. Occasionally, doctors may well alter your dosage from those demonstrated beneath.
Serious Allergic Reactions. Sildenafil might lead to allergic reactions, that may be severe. Quit having sildenafil and acquire assistance without delay When you have any of the subsequent symptoms of a serious allergic reaction.
In the event you observe alterations with ejaculation Whilst you’re taking Viagra, inform your medical professional. They’ll find a way to help you determine what’s causing these variations.
VIAGRA might be taken with or with no meals. If you take VIAGRA after a large Extra fat meal (such as a cheeseburger and french fries), VIAGRA may perhaps just take somewhat more time to get started on working
You could have listened to Viagra referred to as the “little blue tablet.” Viagra comes to be a tablet that you choose to swallow. It’s a blue tablet that includes a rounded diamond form.
Sexual exercise can place an extra strain on your coronary heart, especially if your coronary heart is already weak from the heart assault or heart problems. Question your physician if your heart is healthy adequate to take care of the additional strain of having intercourse.
Indicate sildenafil plasma concentrations calculated once the administration of one oral dose of 100 mg to nutritious male volunteers is depicted below:
Viagra may perhaps cease Doing work as a result of physiological and psychological changes in Your entire body. Learn more with regards to the will cause and Anything you can seek to help with…
Based upon animal data, VIAGRA is not predicted to raise the possibility of adverse developmental results in human beings.
Sildenafil functions by blocking an enzyme in the human body referred to as PDE5, which allows take it easy particular blood vessels. For erectile dysfunction, it increases blood stream into the penis when aroused.
Don't take sildenafil Should you be also using a nitrate drug for upper body ache or coronary heart troubles. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate.
Your health care provider may have suggested this medication for conditions other than Those people mentioned in these drug facts article content.
Nevertheless, in vitro studies with human platelets point out that sildenafil potentiates the antiaggregatory influence of sodium nitroprusside (a nitric oxide donor). Furthermore, The mix of heparin and VIAGRA had an additive impact get more info on bleeding time in the anesthetized rabbit, but this interaction hasn't been analyzed in individuals.